Hordes of akuma are arriving in Edo to join the Earl, who has found a nefarious use for one of the greatest of all Biblical artefacts. Meanwhile, one akuma has invaded the Asian Branch of the Dark Order to take care of Allen once and for all. Allen doesn't appear to stand a chance, but the very nature of the akuma's attack starts something no one could have anticipated, and might wind up changing the fate of the world!

因為科穆伊室長所製造的病毒，使得科學班成員接連地變成了殭屍，並且開始襲擊亞連等人。為阻止感染源的擴散而開始進行抗體的製作，但柯洛利卻在這時覺醒，出現了不可思議少女的靈魂！事件的真相究竟是怎麼一回事？

在教團本部展開瘋狂殺戮的等級４，目標指向了科穆伊…在這窮途末路之時利娜莉自己將INNOCENCE注入體內而得到了新的力量！再加上不斷持續激戰的亞連，教團方面終於開始反擊！

與神田對峙的林克……林克奉魯貝里亞之命，站在守護「第１４號」這一方！另一方面，竟發生了亞連蠻不在乎地傷害了喬尼的事態。內亞似乎正一步步地覺醒當中……即便如此，喬尼仍下定決心要和亞連一同前進──！